今日药学

2019, v.29(09) 417-419

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临床药师参与1例尼美舒利致急性肾损伤的临床实践
Clinical Practice of Clinical Pharmacist Involved in A Case of Acute Kidney Injury Caused by Nimesulide

陈华炎;潘裕华;陶一鸣;叶智明;劳海燕;
CHEN Huayan;PAN Yuhua;TAO Yiming;YE Zhiming;LAO Haiyan;Department of Pharmacy,Affiliated Hospital of Guangdong Medical University;Department of Pharmacy,Guangzhou,Guangdong Provincial People′s Hospital/Guangdong Academy of Medical Sciences;Department of Nephrology,Guangzhou,Guangdong Provincial People′s Hospital/Guangdong Academy of Medical Sciences;

摘要(Abstract):

目的探讨药师参与尼美舒利诱发急性肾损伤病例的药学实践。方法报告1例痛风性关节炎患者在使用尼美舒利分散片后出现急性肾损伤。结果在治疗过程中,临床药师及时发现急性肾损伤为尼美舒利不良反应,建议医生停用尼美舒利。停用尼美舒利后,给予碳酸氢钠片碱化尿液促进药物排泄等对症治疗,血肌酐逐渐恢复至基线水平。结论临床药师参与药物性急性肾损伤治疗,可协助医生提高药物治疗水平及保障患者的用药安全。
OBJECTIVE To explore the role of pharmacist in the management of one patient with acute kidney injury induced by nimesulide. METHODS One patient with gouty arthritis was reported acute kidney injury after using nimesulide dispersible tablets. RESULTS During the treatment,the clinical pharmacists promptly found that the acute kidney injury maybe induced by nimesulide,and recommended the doctor to discontinue nimesulide. After stopping nimesulide,giving sodium bicarbonate tablets alkalinizing urine to promote drug excretion,the serum creatinine had restored to normal. CONCLUSION The participation of clinical pharmacists in the treatment of drug-induced acute kidney injury could help doctors improve the level of drug treatment and ensure the medication safety.

关键词(KeyWords): 尼美舒利;急性肾损伤;临床药师;药学监护;不良反应
nimesulide;acute kidney injury;clinical pharmacist;pharmaceutical care;adverse reactions

Abstract:

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基金项目(Foundation): 广东省医院药学研究基金(2019A21)

作者(Author): 陈华炎;潘裕华;陶一鸣;叶智明;劳海燕;
CHEN Huayan;PAN Yuhua;TAO Yiming;YE Zhiming;LAO Haiyan;Department of Pharmacy,Affiliated Hospital of Guangdong Medical University;Department of Pharmacy,Guangzhou,Guangdong Provincial People′s Hospital/Guangdong Academy of Medical Sciences;Department of Nephrology,Guangzhou,Guangdong Provincial People′s Hospital/Guangdong Academy of Medical Sciences;

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