韩珂;叶丽卡;吴传斌;
HAN Ke1,YE Li-ka1,WU Chuan-bin2(1.The Second Affiliated Hospital of Guangzhou Medical College,Guangzhou,Guangdong 510260,China; 2.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong 510006,China)

• 1:广州医学院第二附属医院
• 2:中山大学药学院

摘要(Abstract)：

目的制备并评价一种用于血管内栓塞治疗肝癌的液体性栓塞材料原位植烷三醇立方液晶。方法以植烷三醇为液晶材料,采用溶致液晶法制备原位植烷三醇立方液晶并评价其性能,运用偏光显微镜(PLM)、差示扫描量热法(DSC)、显微拉曼光谱法、小角X射线散射法(SAXS)及流变学等手段确证其吸水溶胀后的液晶晶相。结果原位植烷三醇立方液晶黏度低,适于注射,经检测证明其能吸水溶胀转变成高黏度的具有生物黏附性能的植烷三醇立方液晶。结论体外实验结果表明,原位植烷三醇立方液晶具有良好的流动性及原位特性。
Objective To prepare and evaluate a liquid embolic material of in situ phytantriol cubic liquid crystalline for the treatment of hepatocellular carcinoma.Methods The in situ cubic liquid crystalline based on phytantriol was prepared using lytropic liquid crystalline technology.The behaviors of in situ phytantriol cubic liquid crystalline under contacting with dissolution fluids were investigated in details by polarized light microscopy(PLM),differential scanning calorimetry(DSC),small angle X-ray scattering(SAXS),resonance Raman spectroscopy,and rheological measurements.Results The injectable in situ phytantriol cubic liquid crystalline was formed and could transform into the cubic liquid crystalline upon contacting the dissolution fluids.Conclusion in situ phytantriol cubic liquid crystalline has good fluidity and in situ characteristics in vitro.

关键词(KeyWords)： 原位;植烷三醇;立方液晶;性能
in situ;phytantriol;cubic liquid crystaline;characterization

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(编号:81202477)

作者(Authors): 韩珂;叶丽卡;吴传斌;
HAN Ke1,YE Li-ka1,WU Chuan-bin2(1.The Second Affiliated Hospital of Guangzhou Medical College,Guangzhou,Guangdong 510260,China; 2.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong 510006,China)

参考文献(References)：

• [1]Lau WY,Lai EC,Lau SH.The current role of neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy forhepatocellular carcinoma:a systematic review[J].Hepato-biliary Pancreat Dis Int,2009,8(2):124-133.
• [2]Lau WY,Lai EC.Hepatocellular carcinoma:current man-agement and recent advances[J].Hepatobiliary PancreatDis Int,2008,7(3):237-257.
• [3]Yoon CJ,Chung JW,Park JH,et al.Transcatheter arterialchemoembolization with paclitaxel-lipiodol solution in rabbitVX2 liver tumor[J].Radiology,2003,229(1):126-131.
• [4]Luzzati V,Tardieu A,Bulik-Krzywicki T.Polymorphism oflipids[J].Nature,1968,217(5133):1028-1030.
• [5]Shah JC,Sadhale Y,Chilukuri DM.Cubic phase gels asdrug delivery systems[J].Adv Drug Deliv Rev,2001,47(2-3):229-250.
• [6]Sadhale Y,Shah JC.Biological activity of insulin in GMOgels and the effect of agitation[J].Int J Pharm,1999,191(1):65-74.
• [7]韩珂,王周华,董怡萱,等.新型血管内栓塞材料原位植烷三醇立方液晶的生物相容性考察及体内评价[J].中国药学杂志,2010,45(8):611-616.
• [8]Barauskas J,Tomas L.Phase behaviour of the phytantriol/water system[J].Langmuir,2003,19(23):9562-9565.
• [9]Chang CM,Bodmeier R.Swelling of and drug release frommonoglyceride-based drug delivery systems[J].J PharmSci,1997,86(6):747-752.
• [10]Misiūnas A,Talaikyte Z,Niaura G,et al.Thermomyceslanuginosus lipase in the liquid-crystalline phases of aque-ous phytantriol:X-ray diffraction and vibrational spectro-scopic studies[J].Biophys Chem,2008,134(3):1441-1456.
• [11]Misiūnas A,Talaikyte Z,Niaura G,et al.Raman and in-frared spectroscopic study of phytantriol and phytantriol-water cubic phases[J].Biologija,2004,4:26-29.
• [12]Carlos RA,Miguel GR,Hironobu K.Rheology and dy-namics of micellar cubic phases and related emulsions[J].Langmuir,2004,20(13):5235-5240.
• [13]Chang CM,Bodmeier R.Low viscosity monoglyceride-based drug delivery systems transforming into a highly vis-cous cubic phase[J].Int J Pharm,1998,173(1-2):51-60.