今日药学

2019, v.29(05) 347-349

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1例辛伐他汀联合环孢素致横纹肌溶解的病例分析
A Case-analysis of Rhabdomyolysis Induced by Combined Use of Simvastatin and Cyclosporine

朱江尉;黄碧瑜;潘裕华;劳海燕;
ZHU Jiangwei;HUANG Biyu;PAN Yuhua;LAO Haiyan;Department of Pharmacy,The Third Affiliated Hospital of Southern Medical University;Department of Pharmacy,Guangdong Provincial People's Hospital;

摘要(Abstract):

目的探讨辛伐他汀联合环孢素导致横纹肌溶解的相互作用机制。提出联用环孢素时,他汀类药物的选择及剂量调整建议,为临床合理用药提供参考。方法通过药学问诊了解患者病史及用药史,查阅相关文献对案例进行分析。结果患者横纹肌溶解的不良反应为辛伐他汀联合环孢素所致。结论临床上应警惕药物的相互作用,临床药师应对使用他汀类药物治疗的患者所服用的所有药物进行审核,通过剂量调整,加强血清肌酶监测或换用相互作用较小的替代药物评估和妥善管理,促进临床合理用药。
OBJECTIVE To explore the interaction mechanism of simvastatin combined with cyclosporine induced rhabdomyolysis.Propose recommendation for statin selection and dose adjustment when used combined with cyclosporine,and provide reference for rational drug use in clinical treatment. METHODS Analyze the case by asking the patient's medical history,medication history and reviewing literature. RESULTS Rhabdomyolysis in this case was induced by concurrent use of simvastatin and cyclosporine. CONCLUSION Great importance should be attached to drug interactions between statins and other medications.Statin drug-drug interactions can be managed by implementing doses adjustments,transferring to another statin,and monitoring of creatinine kinase

关键词(KeyWords): 辛伐他汀;环孢素;横纹肌溶解;药物不良反应
simvastatin;cyclosporine;rhabdomyolysis;adverse drug reaction

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基金项目(Foundation): 广东省医院药学研究基金(2019A21)

作者(Author): 朱江尉;黄碧瑜;潘裕华;劳海燕;
ZHU Jiangwei;HUANG Biyu;PAN Yuhua;LAO Haiyan;Department of Pharmacy,The Third Affiliated Hospital of Southern Medical University;Department of Pharmacy,Guangdong Provincial People's Hospital;

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