今日药学

2014, v.24(07) 514-517

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门诊糖尿病治疗药物应用的调查及合理性探讨
Investigation and Rationality Analysis of Drugs Utilization for Diabetes Therapy in Outpatient Department of A Hospital

伍俊妍;张亮;苏晨;李曼容;
WU Junyan;ZHANG Liang;SU Chen;LI Manrong;Department of Pharmacy,SunYat-Sen Memorial Hospital,Sun Yat-Sen University;Guangdong Pharmaceutical University;

摘要(Abstract):

目的调查分析中山大学孙逸仙纪念医院门诊糖尿病治疗药物应用的基本情况。方法以本院2013-01诊断含有"糖尿病"的7 270张处方为样本,通过统计用药频度DDDs、处方比例、金额排序、联合用药等情况进行调查及合理性探讨。结果胰岛素类似物的使用频率是胰岛素2倍;口服降糖药物的用药频度及处方比例的排名一致,前3位是:双胍类、磺酰脲类、α-糖苷酶抑制剂;降糖药的联合应用处方占降糖药总处方数的36.76%,其中二甲双胍联合用药的占联合用药比例占80.84%,西格列汀的联合用药存在超说明书用法。结论各类药品的使用以及联合用药情况与指南推荐用药原则相吻合,其中西格列汀的超说明书联用有依据,本院降糖药应用总体用药的类别及品种合理。
Objective To investigate and analyze the basic situation of drugs utilization for diabetes therapy in outpatient department of SunYat-Sen Memorial Hospital. Methods A total of 7 270 prescriptions diagnosed with diabetes in January2013 were selected from the hospital. Defined daily doses( DDDs),frequency of prescriptions,rank of sum and drug combination were statistically analyzed. The rationality was discussed. Results The DDDs of insulin analogues were the double of insulin. The ranking of DDDs and prescription proportion of oral antidiabetic drugs were the same. The top 3were biguanides,sulfonylureas and α-glucosidase inhibitors. In all prescriptions of antidiabetic drugs,drug combination application accounted for 36. 76%,in which the combined application of dimethyldiguanide accounted for 80. 84%. The combined application of Januvia was off-label drug application. Conclusion The drug application and combination were consistent with the principle of medication recommended by guidelines. The off-label drug application of Januvia was evidence-based. The overall categories and types of antidiabetic drugs applied in the hospital were reasonable.

关键词(KeyWords): 糖尿病;治疗药物;调查分析
diabetes;therapy drug;investigation and analysis

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作者(Author): 伍俊妍;张亮;苏晨;李曼容;
WU Junyan;ZHANG Liang;SU Chen;LI Manrong;Department of Pharmacy,SunYat-Sen Memorial Hospital,Sun Yat-Sen University;Guangdong Pharmaceutical University;

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