今日药学

2014, v.24(03) 204-206

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治疗类风湿性关节炎处方分析
Analysis for Treatment of Rheumatoid Arthritis Prescriptions

伍俊妍;林茵;何志超;张涛;
WU Jun-yan;LIN Yin;HE Zhi-chao;ZHANG Tao;Sun Yat-sen Memorial Hospital,Sun Yat-sen University;

摘要(Abstract):

目的分析治疗类风湿性关节炎(RA)处方的药物使用情况,对其合理性进行评价。方法选取本院2013-01~06治疗类风湿性关节炎的门诊处方2 510张进行处方分析,通过查阅国内外指南、MICROMEDEX HealthCare Series数据库、国内外文献等方式对处方进行合理性评价。结果所分析处方治疗RA的药物主要是非甾体抗炎药、改善病情抗风湿药(DMARDs)、生物制剂、糖皮质激素、植物药制剂;辅助用药主要有质子泵抑制剂、影响骨代谢药物及钙调节剂、叶酸;超说明书用药有甲氨蝶呤、羟氯喹、环孢素、环磷酰胺,超说明用药有指南推荐,有较好的询证医学证据级别。结论所评价处方的药物选择和联用药物均有指南支持,说明书外用法有合理的医学实践证据,辅助用药用药有用药依据,处方合理。
Objective To investigate the application of drugs for treating rheumatoid arthritis( RA),and assess the rational application of medications. Methods A total of 2 510 outpatient prescriptions of RA in the hospital were selected from January to July,in 2013. International guidelines,MICROMEDEX HealthCare Series database,Chinese and foreign language literatures were used to evaluate the rationality. Results Main prescription drugs for RA include non-steroidal antiinflammatory drugs,disease-modifying anti-rheumatic drugs( DMARDs),biological agents,corticosteroids and herbal medicine; adjuvant drugs consist of proton pump inhibitors,affecting bone metabolism drugs,calcium modulators and folic acid; off-label drugs include methotrexate,droxychloroquine,cyclophosphamide and cyclosporine. Off-label prescriptions were supported by evidence-based guidelines. Conclusion The prescription drugs and combination therapy are recommended by guidelines,off-label drugs are reasonable according to clinical practice evidence,and adjuvant drugs are supported by evidence. The application of drugs for RA in the hospital is reasonable in general.

关键词(KeyWords): 类风湿性关节炎;处方分析
rheumatoid arthritis;prescription analysis

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作者(Author): 伍俊妍;林茵;何志超;张涛;
WU Jun-yan;LIN Yin;HE Zhi-chao;ZHANG Tao;Sun Yat-sen Memorial Hospital,Sun Yat-sen University;

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