今日药学

2015, v.25(05) 347-349+363

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系统性红斑狼疮处方的超药品说明书用药分析
Analysis of Off-Label Drug Use in Prescriptions in Treatment of Systemic Lupus Erythematosus

吴凯珊;伍俊妍;张俊州;周满如;
WU Kaishan;WU Junyan;ZHANG Junzhou;ZHOU Manru;Sun Yat-sen Memorial Hospital,Sun Yat-sen University;Guangdong Medical College;

摘要(Abstract):

目的分析治疗系统性红斑狼疮处方超说明书用药的合理性。方法选取本院2014-01~12治疗多囊卵巢综合征的门诊处方7 535张进行处方分析,通过查阅国外说明书、国内外指南、MICROMEDEX Health Care Series数据库、国内外文献等方式对该超说明书用法进行合理性评价。结果超说明书用药药物包括地塞米松、复方环磷酰胺片、吗替麦考酚酯胶囊/片、甲氨蝶呤片/针剂、他克莫司、沙利度胺片,超说明书处方所占处方比例为:39.06%。地塞米松、复方环磷酰胺片、吗替麦考酚酯胶囊/片、甲氨蝶呤片/针剂、他克莫司、沙利度胺片超说明书用药均有国内外指南推荐,有较好的询证医学证据级别。结论所评价处方的超说明书用药有指南推荐或有合理的医学实践证据,患者用药有指征,处方合理。
OBJECTIVE To analyze the rationality of off-label drug use in prescriptions in the treatment of systemic lupus erythematosus. METHODS A total of 7 535 outpatient prescriptions in the treatment of systemic lupus erythematosus selected from January to December 2014 in the hospital were analyzed. Rationality of the off-label drug use was evaluated by searching foreign package inserts,guidelines at home and abroad,MICROMEDEX Health Care Series database,domestic and foreign literatures and so on.RESULTS Drugs with off-label use included dexamethasone,cyclophosphamide,mycophenolate mofetil,methotrexate,tacrolimus and thalidomide tablets. 39. 06% of prescriptions involved in off-label drug use. Conclusion The off-label use in metformin,spironolactone and letrozole were recommended by domestic and overseas guidelines,with better level of evidence of evidence-based medicines. CONCLUSION The evaluated off-label drug use in prescriptions were recommended by guidelines or with rational evidence of medical practice. The drug applications in patients were according to indications,the prescriptions were reasonable.

关键词(KeyWords): 系统性红斑狼疮;超说明书用药;分析
systemic lupus erythematosus;off-label drug use;analysis

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作者(Author): 吴凯珊;伍俊妍;张俊州;周满如;
WU Kaishan;WU Junyan;ZHANG Junzhou;ZHOU Manru;Sun Yat-sen Memorial Hospital,Sun Yat-sen University;Guangdong Medical College;

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