复方a-酮酸片联合低蛋白饮食治疗慢性肾功能不全的临床观察Clinical Effect of Compound α-Ketoacid Combined with Low Protein Diet on Patients with Chronic Renal Failure
吴国锋;陈锐;
WU Guo-feng,CHEN Rui(Department of Medicine,Li-Wan Hospital of Guangzhou Medicine College,Guangzhou,Guangdong 510170,China)
摘要(Abstract):
目的观察复方a-酮酸片联合低蛋白饮食改善慢性肾功能不全患者氮质血症、贫血、蛋白代谢、钙磷代谢的作用。方法将160例慢性肾功能不全患者随机分为2组,以低蛋白饮食为对照组,观察复方a-酮酸片联合低蛋白饮食治疗6个月前后各生化指标的变化。结果治疗后血浆白蛋白、尿素氮、血肌酐、血钙、血磷、碳酸氢根均较治疗前有明显改善,有统计学差异(P<0.05)。结论复方a-酮酸片联合低蛋白饮食能减轻慢性肾功能不全患者的肾脏负担,延缓肾功能进展,延长患者的生存期。
Objective To investigate the effect of compound α-Ketoacid combined with low protein diet on symptoms of azotemia,anemia,protein metabolism,and calcium-phosphorus metabolism in patients with chronic renal failure.Methods Compound α-Ketoacid combined with low protein diet were prescribed to 80 chronic renal failure patients,and were followed up to trace changes in biochemical indices.Result Significant improvements were observed in serum levels of albumin,blood urea nitrogen,creatinine,calcium,phosphorus,bicarbonate.Conclusion Compound α-Ketoacid combined with low protein diet may alleviate the burden on kidneys,retard the deterioration of renal function,and improve quality of life.
关键词(KeyWords):
复方a-酮酸片;低蛋白饮食;慢性肾功能不全
compound α-Ketoacid;low protein diet;chronic renal failure
基金项目(Foundation):
作者(Authors):
吴国锋;陈锐;
WU Guo-feng,CHEN Rui(Department of Medicine,Li-Wan Hospital of Guangzhou Medicine College,Guangzhou,Guangdong 510170,China)
参考文献(References):
- [1]王虹,王爱香,刘淑娟.开同改善慢性肾衰患者脂代谢紊乱的临床观察[J].中国误诊学杂志,2008,8(35):8620.
- [2]顾惠芳,朱栋良.低蛋白饮食加复方α-酮酸片治疗在延缓肾功能衰竭中的作用[J].医学临床研究,2011,28(9):1818-1819.
- [3]王海燕.肾脏病学[M].第二版,北京:人民卫生出版社,2001:597.
- [4]Eyre S,Attman PO,Haraldsson B.Positive effects of pro-tein restriction in patients with chronic kidney disease[J].JRen Nutr,2008,18(3):269-280.
- [5]张海燕,梁摇伟,杨铁城,等.左卡尼汀对血液透析患者营养状况及氧化应激的影响[J].今日药学,2010,20(8):34-36.
- [6]陈欣,陈忠辉,汪炜,等.开同对维持性血液透析患者营养状况影响的观察[J].中国伤残医学,2009,17(6):26-28.
- [7]Mir S,Ozkayin N.The role of keto acids in the supportivetreatment of children with chronic renal failure[J].PediatrNephrol,2005,20(7):950-955.
- [8]罗群,郑丽容,刘华珍.促红细胞生成素联合辛伐他汀对血液透析患者微炎症及贫血的影响[J].今日药学,2009,19(7):27-29.
- [9]Teplan V,Schuck O,Horackova M,et al.Effect of a ketoacidamino acid supplement on the metabolism and renalelimination of branched-chain amino acids in patients withchronic renal insufficiency on a low protein diet[J].WienKlin Wochensch,2000,112(20):876-881.
- [10]张红梅,俞东容,徐桂美,等.不同低蛋白饮食疗法延缓慢性肾功能衰竭进程的实验研究[J].浙江医学,2010,32(6):815-818.
- [11]Levey AS,Greene T,Samak MJ,et al.Effect of dietaryprotein restriction on the progression of kidney disease:longterm follow up of the modification of diet in renal disease(MDRD)study[J].Am J Kidney Dis,2006,48(6):879-888.
- [12]刘杰,冯烈,卢筱华,等.复方血栓通胶囊对糖尿病肾病的疗效观察[J].今日药学,2012,22(5):289-292.