古伟光,陈丽昆,梁颖,黄河,徐光川
GU Wei guang; CHEN Li kun; LIANG Ying; HUANG He; XU Guang chuan Department of medical oncology, NanHai people's hospital. NanHai 528200 P. R. China; Cancer Center, Sun Yat-sen University,Guangzhou 510060, P. R. China

• 1:南海人民医院肿瘤科广东
• 2:中山大学肿瘤防治中心
• 3:中山大学肿瘤防治中心
• 4:中山大学肿瘤防治中心

摘要(Abstract)：

目的 通过前瞻性随机对照临床试验,探讨四环素、顺铂、氟美西诺(胞必佳)3种药物治疗非小细胞肺癌(NSCLC)恶性胸腔积液疗效和不良反应。方法 105例经组织学或细胞学确诊的NSCLC恶性胸腔积液患者胸水引流后,随机分为3组,胸腔内分别注入四环素500mg、顺铂100mg或胞必佳600μg,2周后复查胸片评价疗效。结果 105例患者胸腔注药后的总有效率为69.5％;四环素组有效率为73.5％,中位缓解期为7.3个月;顺铂组有效率为66.7％,中位缓解期为5.7个月;氟美西诺组有效率为68.6％,中位缓解期为7.1个月;3组有效率无统计学差异。治疗不良反应有不同程度发热、胸病及胃肠道反应,无骨髓抑制及肝肾损害。结论 四环素、顺铂、氟美西诺是治疗NSCLC恶性胸腔积液的有效药物,有效率相当,不良反应各异。
Objective This prospective randomized study is to evaluate the efficacy and side effect of pleural space perfusion with Tet- racycline,Cisplatin (DDP) and Flumecinol (N-CWS) in treating malignant pleural effusion in non-small cell lung cancer (NSCLC) patients. Method 105 NSCLC patients with malignant pleural effusion were randomized into three groups. group 1: Tetracycline 500mg, group 2:DDP 100mg, group 3: N-CWS 600mg. The three drugs were perfused into thoracic cavity after drainage of the pleu- ral effusion. Efficacy was evaluated two weeks later by chest X-ray examination. Result The overall response rate was 69. 5% and 73. 5% for group 1, 66. 7% for group 2, 68. 6% for group 3 respectively. There is no statistically difference of response rate between the three groups. The medium TTP was 7. 3 months for group 1, 5. 7 months for group 2, 7. 1 months for group 3. The main adverse effects contain different degrees of fever, chest pain, and nausea, vomiting. There is no myelosuppression and damage of liver and kid- ney function. Conclusion Pleural space perfusion with Tetracycline, DDP or N-CWS was effective in treating malignant pleural effu- sion of NSCLC patients. The response rate had no difference statistically whereas the side effects showed some difference in three groups.

关键词(KeyWords)： 恶性胸腔积液;非小细胞肺癌;四环素;顺铂;氟美西诺
Malignant pleural effusion;Non-small cell lung cancer (NSCLC);Tetracycline;cisplatin (DDP);Flumecinol (NCWS)

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 古伟光,陈丽昆,梁颖,黄河,徐光川
GU Wei guang; CHEN Li kun; LIANG Ying; HUANG He; XU Guang chuan Department of medical oncology, NanHai people's hospital. NanHai 528200 P. R. China; Cancer Center, Sun Yat-sen University,Guangzhou 510060, P. R. China

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