今日药学

2020, v.30(09) 638-640

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40例喹硫平治疗双相情感障碍的不良反应相关因素分析
Correlation Factors Analysis of 40 Cases Adverse Drug Reactions Induced by Quetiapine in the Treatment for Bipolar Disorder

于东港;曾晓云;陈宏镇;王占璋;卢浩扬;谢焕山;倪晓佳;张明;张建萍;尚德为;温预关;
YU Donggang;ZENG Xiaoyun;CHEN Hongzhen;WANG Zhanzhang;LU Haoyang;XIE Huanshan;NI Xiaojia;ZHANG Ming;ZHANG Jianping;SHANG Dewei;WEN Yuguan;The Affiliated Brain Hospital of Guangzhou Medical University;College of Pharmacy,Jinan University;The Seventh Affiliated Hospital of Sun Yat-sen University;

摘要(Abstract):

目的分析喹硫平在治疗双相情感障碍发生不良反应的特点和分布规律,为喹硫平治疗双相情感障碍的安全性提供参考。方法收集我院2014~2018年上报至国家不良反应监测中心关于喹硫平治疗双相情感障碍的40例不良反应报告,对相关因素进行统计分析。结果收集的40例不良反应报告中,年龄主要分布在19~40岁,女性多于男性。不良反应累及的系统以神经系统最常见(25%),其次为皮肤及软组织系统(19.6%)。不良反应以合并用药时较为常见,有77.5%给予400~800mg·d~(-1)的患者发生不良反应,血药谷浓度低于100 ng·mL~(-1),也可能发生严重ADR。此外,有42.5%的患者在减少剂量后均出现好转或痊愈。结论临床上应重视喹硫平用于治疗双相情感障碍时产生的不良反应,并应加强监测。如果在治疗过程中发生不良反应,可以采取降低剂量甚至停药、对症治疗等措施。
OBJECTIVE To analyze the characteristics and distribution of adverse drug reactions(ADR) induced by quetiapine in the treatment for bipolar disorder,so as to provide reference for the safe use of quetiapine.METHODS A total of 40 cases of ADR patients reported to the National Adverse Drug Reaction Monitoring Center from 2014 to 2018 in Guangzhou Huiai Hospital were collected.The correlation factors of ADR were statistically analyzed.RESULTS Among the 40 ADR cases,the age of patients ranged from 19 to 40 years old and the proportion of female patients was more than male patients.ADR were characterized by damages of nervous system(25%) and impairment of skin and accessories system(19.6%).ADR were more common in patients with concomitant medication.ADR occurred in 77.5% of the patients who were given a dose of 400 to 800 mg·d~(-1).Serious ADR could occur in patients with a serum quetiapine concentration was lower than 100 ng·mL~(-1).In addition,42.5% of the patients showed improvement or recovery after the dose reduction.CONCLUSION Great attention should be paid on ADR induced by quetiapine in the treatment for bipolar disorder.Measures should be taken to the ADR such as dose reduction even stopping medication and symptomatic treatment.

关键词(KeyWords): 喹硫平;不良反应;双相情感障碍
quetiapine;adverse reaction;bipolar disorder

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Keywords:

基金项目(Foundation): 广东省医院药学研究基金(2019A01);; 广州市医学重点学科建设项目(2017-2019);; 广东省科技计划项目(2019B030316001);; 广州市科技计划项目(201805010009)

作者(Author): 于东港;曾晓云;陈宏镇;王占璋;卢浩扬;谢焕山;倪晓佳;张明;张建萍;尚德为;温预关;
YU Donggang;ZENG Xiaoyun;CHEN Hongzhen;WANG Zhanzhang;LU Haoyang;XIE Huanshan;NI Xiaojia;ZHANG Ming;ZHANG Jianping;SHANG Dewei;WEN Yuguan;The Affiliated Brain Hospital of Guangzhou Medical University;College of Pharmacy,Jinan University;The Seventh Affiliated Hospital of Sun Yat-sen University;

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