今日药学

2019, v.29(10) 673-676

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广东土牛膝石油醚提取物的GC-MS分析
The Analysis of Petroleum Ether Extract in Eupatorium Chinese( Guangdong Tuniuxi) by GC-MS

袁德俊;吴启端;
YUAN Dejun;WU Qiduan;The Affiliated Orthopedics and Traumatology Hospital of Guangzhou University of Traditional Chinese Medicine;The First Affiliated Hospital of Guangzhou University of TCM;

摘要(Abstract):

目的分析广东土牛膝石油醚提取物的化学成分,为其质量评价提供依据。方法采用气相色谱-质谱联用(GC-MS)法建立10批广东土牛膝石油醚提取物的指纹图谱,对其中的化学成分进行分析鉴定,确定10批样品的共有成分,用峰面积归一化法计算各成分的相对百分含量。以平均相对百分含量大于1%的共有成分为指标进行聚类分析。结果共鉴定31个化学成分,10批样品有35个共有成分。共有成分的平均相对含量合计为90.458%,已鉴定的共有成分平均相对含量合计为86.228%,含量最高的是Liguhodgsonal,为59.228%。聚类分析结果将10批药材分为4小类,各包含的样品数为5、3、1、1;各类样品共有成分平均相对含量合计(及主成分Liguhodgsonal含量)分别为97.191%(67.613%)、89.076%(50.756%)、60.947%(42.712%)、89.556%(34.118%)。结论广东土牛膝石油醚提取物的主要成分是Liguhodgsonal。
OBJECTIVE To Analyze the chemical constituents of petroleum ether extract from Guangdong tuniuxi. METHODS The fingerprint chromatography of 10 batchs of petroleum ether extract of Eupatorium Chinese was established by GC-MS chromatography,The chemical composition was analyzed and identified,the relative content of various substances was calculate by peak area normalization method. Cluster analysis was performed with the average relative content of more than 1%. RESULTS A total of 31 chemical constituents were identified,and 35 kinds of common ingredients in the 10 batches of samples were identified. The 10 batches of medicinal materials were divided into 4 groups,with number of samples included is 5,3,3,1,respectively. The average relative content of total components Liguhodgsonal of all kinds of samples was 97. 191%( 67. 613%),89. 076%( 50. 756%),60. 947%( 42.712%),89.556%( 34. 118%),respectively. CONCLUSION The main constituents of Eupatorium Chinese petroleum ether extract is Liguhodgsonal.

关键词(KeyWords): 广东土牛膝;指纹图谱;气相色谱-质谱联用;聚类分析
Eupatorium Chinese;fingerprint;gas chromatography-mass spectrometry;cluster analysis

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作者(Authors): 袁德俊;吴启端;
YUAN Dejun;WU Qiduan;The Affiliated Orthopedics and Traumatology Hospital of Guangzhou University of Traditional Chinese Medicine;The First Affiliated Hospital of Guangzhou University of TCM;

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