今日药学

2019, v.29(10) 716-720

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中药有效成分对舌鳞癌作用机制的研究进展
Research Progress on the Action Mechanism of Chinese Herbal Ingredients Against Tongue Squamous Cell Carcinoma

蓝紫连;潘宣;
LAN Zilian;PAN Xuan;Department of Stomatology,the First Affiliated Hospital of Guangdong Pharmaceutical University;

摘要(Abstract):

目的通过整理国内外中药有效成分抗舌鳞癌作用机制的研究现状以寻求进一步筛选优质抗癌药物成分。方法检索CNKI、万方、维普等中文数据库以及PubMed等外文数据库,检索时间均从建库至2019-02-07,共纳入了52篇文献。结果中药有效成分通过抑制细胞增殖、促凋亡、抑制转移等作用机制实现抗舌鳞癌作用。结论经研究证明,一部分中药有效成分抗舌癌作用显著,具有良好临床应用前景。
OBJECTIVE To summarize the current research status of the anti-tongue squamous cell carcinoma mechanism of Chinese herbal medicine ingredients at home and abroad and search for effective anti-tumor ingredients of Chinese herbal. METHODS Chinese databases such as CNKI,Wanfang and Weipu,as well as foreign language databases such as PubMed were retrieved,and the retrieval time was from the database establishment to 2019-02-07. According to the inclusion criteria,52 references were finally included after selection. RESULTS By inhibiting cell proliferation,promoting apoptosis,inhibiting metastasis and other mechanisms,the Chinese herbal ingredients could achieve the effect of anti-tongue squamous cell carcinoma. CONCLUSION Proved by experiment,some effective Chinese herbal ingredients have significant effect on tongue cancer,which have a good exploration prospect.

关键词(KeyWords): 中药成分;舌鳞癌;增殖及凋亡;转移;作用机制
Chinese herbal ingredients;tongue squamous cell carcinoma;proliferation and apoptosis;metastasis;action mechanism

Abstract:

Keywords:

基金项目(Foundation): 广东省科技发展专项资金项目(2016A020215154);; 广东省特色创新项目(2016KTSCX066)

作者(Authors): 蓝紫连;潘宣;
LAN Zilian;PAN Xuan;Department of Stomatology,the First Affiliated Hospital of Guangdong Pharmaceutical University;

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